About every 40-45 miles along the Florida Turnpike (which runs from Wildwood to Miami -- some 275 miles) there are plazas which offer a respite for tired drivers. You can buy gasoline, food, and assorted other goodies. Most important they offer restrooms.
When we first moved to Florida in 1985, these plazas were awful dumps! Through the years, however, they have been upgraded and now are quite pleasant. The authorities work very hard to keep the restrooms and other areas clean.
It is 300 miles from Ocala to Fort Lauderdale. This is the Fort Drum plaza which is approximately half-way.